| Date | Payload | Launcher | Launch Site | Notes |
| 15 January | NROL-49 | Delta 4 Heavy | Vandenberg Air Force Base, California, USA | US spy satellite |
| 20 January | HTV-2 (H-II Transfer Vehicle) | H-2B | Tanegashima Space Centre, Japan | Japanese unmanned cargo vehicle to the International Space Station |
| 28 January | Progress M-09M (ISS 41P) | Soyuz U | Baikonur Cosmodrome, Kazakhstan | unmanned cargo transport to the International Space Station |
| January | AMC 1R | Ariane 5 | CSG Kourou, French Guiana | commercial communications satellite |
| January | NRO L-29 | Atlas V | | US spy satellite |
| January | ORS 1 | Minotaur 1 | Wallops Flight Facility, Wallops Island, Virginia, USA | US military reconnaissance satellite |
| January – March | SBIRS-GEO 1 | Atlas 5 | Cape Canaveral Air Force Station, Florida | |
| January | Spektr-R/RadioAstron | Zenit 3SLBF / Fregat SB | Baikonur Cosmodrome, Kazakhstan | radiotelescope |
| 26 February | Space Shuttle Endeavour ISS-35-ULF5 | Shuttle Endeavour (STS-134) | Kennedy Space Center, Florida, USA | shuttle visit to the International Space Station, delivery of Express Logistics Carrier 3 (ELC3) and Alpha Magnetic Spectrometer (AMS) to ISS |
| 27 February | Dragon C2 (COTS Demo 2) | Falcon IX | Cape Canaveral Air Force Station, Florida, USA | second test flight of the Dragon spacecraft which will demonstrate proximity operations close to the International Space Station |
| February | AEHF F-2 | Atlas 5 | Cape Canaveral Air Force Station, Florida, USA | US military communications satellite |
| February | Afristar 3 | Ariane 5 | CSG Kourou, French Guiana | radio broadcast satellite |
| February | Bluesat | Dnepr-1 | Baikonur Cosmodrome, Kazakhstan | |
| February | GPS 2F-2 | Atlas V | Cape Canaveral Air Force Station, Florida, USA | navigation satellite |
| February | Hausat 2 | Dnepr-1 | Baikonur Cosmodrome, Kazakhstan | |
| February | Insat 4G | Ariane 5 | CSG Kourou, French Guiana | commercial communications satellite |
| February | Intelsat 18 | Zenit 3SLB | Baikonur Cosmodrome, Kazakhstan | commercial communications satellite |
| February | Lapansat 2 | Dnepr-1 | Baikonur Cosmodrome, Kazakhstan | |
| February | NRO L-39 | Atlas V | | US spy satellite |
| February | Terrestar 2 | Ariane 5 | CSG Kourou, French Guiana | commercial communications satellite |
| February | Unamsat 3 | Dnepr 1 | | |
| February | Uragan/Glonass K1/K2 | Soyuz 2-1a / Fregat | | Russian navigation satellites |
| February | Yahsat 1A | Ariane 5 | CSG Kourou, French Guiana | commercial communications satellite |
| 28 March | COTS Demo | Taurus II | | |
| 30 March | Soyuz TMA-21 ISS 26S | Soyuz FG | Baikonur Cosmodrome, Kazakhstan | manned transport vessel to the International Space Station |
| 31 March | LISA Pathfinder / SPACETECH-07 (SMART-2) | | | |
| March | Amos 5, Luch 5A | Soyuz-2 / Fregat | | commercial communications satellite (Amos 5), Russian data relay satellite (Luch 5A) |
| March | Dialog 1 | Rokot-Briz | Plesetsk Cosmodrome, Russia | |
| March | Dragon C3 (COTS Demo 3) | Falcon IX | Cape Canaveral Air Force Station, Florida, USA | |
| March | EuropaSat | Proton M / Briz M | Baikonur Cosmodrome, Kazakhstan | commercial communications satellite |
| March | Express MD-2 | Proton M / Briz M | Baikonur Cosmodrome, Kazakhstan | commercial communications satellites |
| March | Kompsat 5 | Dnepr 1 | Dombarovskiy Launch Site, Yasny, Russia | |
| March | Meteor 3M N2 | Soyuz-2.1b / Fregat | Baikonur Cosmodrome, Kazakhstan | |
| March | NRO | Delta 4 | Cape Canaveral Air Force Station, Florida | US spy satellite |
| March | NRO L-34 | Atlas V | Vandenberg Air Force Base, California, USA | US spy satellite |
| March | Pleiades-HR 1, ELISA 1, ELISA 2, ELISA 3, ELISA 4, SSOT | Soyuz 2-1b / Fregat | CSG Kourou, French Guiana | earth observation satellite (Pleiades-HR 1), four electronic intelligence demonstrator satellites (ELISA) |
| 1 April | Connect | | | |
| 27 April | Progress M-10-M (ISS 42P) | Soyuz U | Baikonur Cosmodrome, Kazakhstan | unmanned cargo transport to the International Space Station |
| April | AFSPC 2 | Atlas V | Cape Canaveral Air Force Station, Florida | |
| April | Elektro-L N1 | Zenit-3 / Fregat | Baikonur Cosmodrome, Kazakhstan | |
| April | SAC-D | Delta 2 | Vandenberg Air Force Base, California, USA | earth observation satellite which will produce global maps of ocean salt concentration |
| April | ViaSat 1 | Proton | Baikonur Cosmodrome, Kazakhstan | commercial communications satellite |
| 31 May | Soyuz TMA-22 ISS 27S | Soyuz FG | Baikonur Cosmodrome, Kazakhstan | manned transport vessel to the International Space Station |
| May | Dragon C4 (CRS 1) | Falcon IX | Cape Canaveral Air Force Station, Florida, USA | |
| May | NRO L-25 | Delta 4-Medium | Vandenberg Air Force Base, California, USA | US spy satellite |
| May | X-37B OTV-2 | Atlas 5 | Cape Canaveral Air Force Station, Florida, USA | US experimental military space plane |
| 21 June | Progress M-11-M (ISS 43P) | Soyuz U | Baikonur Cosmodrome, Kazakhstan | unmanned cargo transport to the International Space Station |
| June | Express AM-4 | Proton M / Briz M | Baikonur Cosmodrome, Kazakhstan | commercial communications satellites |
| June | Galileo IOV1, IOV2 | Soyuz 2-1b / Fregat | CSG Kourou, French Guiana | 2 validation satellites for the Galileo navigation system |
| June | Microscope | Ariane 5 | CSG Kourou, French Guiana | |
| June | | Taurus 2 | Wallops Flight Facility, Wallops Island, Virginia, USA | risk reduction test flight |
| July – September | Intelsat 17 | Zenit 3SL | Sea Launch's Odyssey platform in the Pacific Ocean | commercial communications satellite |
| 5 August | Juno (New Frontiers 2) | Atlas V | Cape Canaveral Air Force Station, Florida | probe to Jupiter |
| 30 August | Progress M-12-M (ISS 44P) | Soyuz U | Baikonur Cosmodrome, Kazakhstan | unmanned cargo transport to the International Space Station |
| August | Cassiope 1 | Falcon 9 | | |
| August | Discovery 12 | Medium | | |
| August | Dragon C5 (ISS Flight 2) | Falcon IX | Cape Canaveral Air Force Station, Florida, USA | |
| August | MIDEX-08 | Delta 2 | | |
| 8 September | Grail A/B (Discovery-11) | Delta 2 Heavy | Cape Canaveral Air Force Station, Florida | lunar probe which will determine the internal structure and the thermal evolution of the Moon |
| 30 September | Soyuz TMA-23 ISS 28S | Soyuz FG | Baikonur Cosmodrome, Kazakhstan | manned transport vessel to the International Space Station |
| September | Cygnus COTS Demo | Taurus 2 | Wallops Flight Facility, Wallops Island, Virginia, USA | |
| September | MIDEX-07 | Delta 2 | | |
| 18 October | NPP-Bridge (NPOESS Preparatory Project) | Delta 2 | Vandenberg Air Force Base, California, USA | Earth observation mission which will measure the Earth's atmospheric and sea surface temperatures, humidity sounding, land and ocean biological activity and cloud and aerosol properties |
| 21 October | Progress M-13-M (ISS 45P) | Soyuz U | Baikonur Cosmodrome, Kazakhstan | unmanned cargo transport to the International Space Station |
| October | Lunar Robotic 3 | Delta | | |
| October - December | Intelsat 23 | Proton | Baikonur Cosmodrome, Kazakhstan | commercial communications satellite |
| October - December | P5-A / Archimedes | Ariane 5 | CSG Kourou, French Guiana | |
| 8 November | Phobus-Grunt, Yinghuo 1 (CDP-1) | Zenit 3F | Baikonur Cosmodrome, Kazakhstan | probes to Mars and its moons |
| 25 November – 18 December | Curiosity (Mars Science Laboratory) | Atlas 5 | Cape Canaveral Air Force Station, Florida, USA | Mars rover which will assess whether Mars was or is suitable for microbial life |
| 30 November | Soyuz TMA-24 ISS 29S | Soyuz FG | Baikonur Cosmodrome, Kazakhstan | manned transport vessel to the International Space Station |
| November | Mars Testbed Lander | Intermediate | | |
| December | AzerSat | | Baikonur Cosmodrome, Kazakhstan | |
| December | Nauka MLM (ISS-03R) | Proton | Baikonur Cosmodrome, Kazakhstan | unmanned cargo transport to the International Space Station carrying Multipurpose Laboratory Module (MLM) with European Robotic Arm (ERA) |
| December | WGS-4 | Delta 4M+ | Cape Canaveral Air Force Station, Florida | US military communications satellite |
| ??? | ATV 3 | Ariane 5 | CSG Kourou, French Guiana | unmanned supply ship to ISS |
| ??? | BSAT 3c, JCSat 110R | Ariane 5 | CSG Kourou, French Guiana | |
| ??? | Demo Launch | Falcon Ie | Reagan Test Site, Kwajalein Atoll, Marshall Islands | first test flight |
| ??? | ExoMars | Soyuz 2-1b / Fregat | CSG Kourou, French Guiana | |
| ??? | Galileo IOV3, IOV4 | Soyuz 2-1b / Fregat | CSG Kourou, French Guiana | 2 validation satellites for the Galileo navigation system |
| ??? | GPS 2F-3 | Atlas V | Cape Canaveral Air Force Station, Florida | US navigation satellite |
| ??? | GPS 2F-4 | Atlas V | Cape Canaveral Air Force Station, Florida | US navigation satellite |
| ??? | GPS 2F-5 | Delta 4 Medium | | US navigation satellite |
| ??? | GPS 2F-6 | Atlas V | | US navigation satellite |
| ??? | GPS 2F-7 | Atlas V | | US navigation satellite |
| ??? | GPS 2F-8 | Atlas V | | US navigation satellite |
| ??? | GPS 2F-9 | Delta 4 Medium | | US navigation satellite |
| ??? | GPS 2F-10 | Delta 4 Medium | | US navigation satellite |
| ??? | LARES (Laser Relativity Satellite), AtmoCube, e-st@r, Goliat, OUFTI-1, PW-Sat 1, ROBUSTA, SwissCube 2, UNICubeSAT, XaTcobeo | Vega | CSG Kourou, French Guiana | first flight of the Vega |
| ??? | NRO L-15 | Delta 4 Heavy | Cape Canaveral Air Force Station, Florida | |
| ??? | Orbcomm 2-1, 2-2, 2-3 | Falcon Ie | Reagan Test Site, Kwajalein Atoll, Marshall Islands | commercial communications satellites |
| ??? | QuetzSat-1 | Proton | Baikonur Cosmodrome, Kazakhstan | commercial communications satellite |
| ??? | Sentinal 1 | Soyuz 2 | CSG Kourou, French Guiana | |
| ??? | SES 3, Kazsat 2 | Proton | Baikonur Cosmodrome, Kazakhstan | commercial communications satellites |
| ??? | Sirius 5 | Proton | Baikonur Cosmodrome, Kazakhstan | commercial communications satellite |
| ??? | Soyuz TMA-24 ISS 28S | Soyuz FG | Baikonur Cosmodrome, Kazakhstan | manned transport vessel to the International Space Station |
| ??? | Svea | Falcon Ie | Reagan Test Site, Kwajalein Atoll, Marshall Islands | |
| ??? | TacSat 1A, Orbcomm FM29 | Falcon 1 | Reagan Test Site, Kwajalein Atoll, Marshall Islands | |
| ??? | Telstar 14R | Proton | Baikonur Cosmodrome, Kazakhstan | commercial communications satellite |
