| Date | Payload | Launcher | Launch Site | Notes |
| March 20 | Echostar 14 | Proton M / Briz M | Baikonur Cosmodrome, Kazakhstan | commercial broadcast satellite |
| March 22 | Dragon Qualification Unit | Falcon 9 | Cape Canaveral Air Force Station, Florida, USA | test launch; first flight of the Falcon 9 |
| March 24 | Astra 3B, ComSat BW-2 | Ariane 5ECA | CSG Kourou, French Guiana | commercial communications satellite (Astra 3B), military communications satellite (ComSat BW-2B) |
| March 25 | Cryosat 2 | Dnepr 1 | Baikonur Cosmodrome, Kazakhstan | European satellite to monitor changes to polar ice |
| March 30 | Gonets D1 M2 – M4, Yubileyniy 2 | Rokot / Briz KM | Plesetsk Cosmodrome, Russia | two Russian communications satellites |
| March | OS 1 (AMC 4R) | Proton M / Briz M | Baikonur Cosmodrome, Kazakhstan | commercial communications satellite |
| March | Sitch 2 | Dnepr 1 | | |
| April 2 | Soyuz TMA-18 ISS 22S | Soyuz FG | Baikonur Cosmodrome, Kazakhstan | manned transport vessel to the International Space Station |
| April 5 | Space Shuttle Discovery ISS-33-19A | Shuttle Discovery (STS-131) | the Kennedy Space Center, Florida, USA | shuttle visit to the International Space Station, delivery of Multipurpose Logistics Module (MPLM) and Lightweight Multi-Purpose Experiment Support Structure Carrier (LMC) to ISS |
| April 6 | Picard, Prisma-Mango, Prisma-Tango | Dnepr 1 | Dombarovskiy Launch Site, Yasny, Russia | climate research satellite (Picard), technology demonstrator satellite pair (Prisma) |
| April 19 | X-37B F-1 (OTV-1) | Atlas 5 | Cape Canaveral Air Force Station, Florida, USA | test flight of USAF prototype Orbital Test Vehicle space plane |
| April 20 | Dummy payload | Minotaur IV | Kodiak Launch Complex, Kodiak Island, Alaska, USA | test flight of Minotaur IV launch vehicle |
| April 22 | Arabsat 5A, COMS 1 | Ariane 5ECA | CSG Kourou, French Guiana | commercial communications satellites |
| April 24 | SES 1 | Proton M / Briz M | Baikonur Cosmodrome, Kazakhstan | commercial communications satellite |
| April 28 | Progress M-05M (ISS 37P) | Soyuz U | Baikonur Cosmodrome, Kazakhstan | unmanned cargo transport to the International Space Station |
| April | Kanopus-V 1, Baumanets 2, Belka 2, Zond-PP | Soyuz FG / Fregat | Baikonur Cosmodrome, Kazakhstan | remote sensing satellite (Kanopus-V 1) |
| April | Electro-L N1 | Zenit-2 / Fregat-SB | Baikonur Cosmodrome, Kazakhstan | Russian meteorological satellite |
| April - June | Sirius FM6 | Proton M / Briz M | Baikonur Cosmodrome, Kazakhstan | commercial radio broadcast satellite |
| April | Zohreh 1 | Soyuz-FG / Fregat | Baikonur Cosmodrome, Kazakhstan | commercial communications satellite |
| May 14 | Space Shuttle Atlantis ISS-34-ULF4 | Shuttle Atlantis (STS-132) | the Kennedy Space Center, Florida, USA | shuttle visit to the International Space Station, delivery of Integrated Cargo Carrier (ICC) and Mini Reserach Module (MRM 1) to ISS |
| May 17 | Akatsuki (Planet-C, Venus Climate Orbiter) | H-2A | Tanegashima Space Center, Kagoshima, Japan | interplanetary probe to Venus |
| May 17 | GPS 2F-1 | Delta 4 | Cape Canaveral Air Force Station, Florida, USA | navigation satellite |
| May 18 | TanDEM-X | Dnepr-1 | Baikonur Cosmodrome, Kazakhstan | synthetic aperture radar imaging satellite |
| May 20 | Planet C (VCO), AWVONS, Ikaros, Negai-Star, Unitec-1, Waseda-Sat2 | H-2A | Tanegashima Space Center, Kagoshima, Japan | |
| May 27 | Nilesat 2, Rascom-QAF 1R | Ariane 5 | CSG Kourou, French Guiana | television broadcast satellite (Nilesat 2), commercial communications satellite (Rascom-QAF 1R) |
| May 28 | STPSat 2 (STP-S26), FalconSat 5, Fastrac A/B, FASTSat-HSV 01, NanoSail D, O/OREOS, RAX | Minotaur IV | Kodiak Launch Complex, Kodiak Island, Alaska, USA | multiple small experimental and technology satellites |
| May 30 | Badr 5 (Arabsat 5B) | Proton M / Briz M | Baikonur Cosmodrome, Kazakhstan | commercial communications satellite |
| May | Yamal 301, Yamal 302 | Proton K / Blok DM2 | Baikonur Cosmodrome, Kazakhstan | commercial communications satellites |
| June 2 | Servis 2 | Rokot / Briz KM | Plesetsk Cosmodrome, Russia | Japanese technology satellite |
| June 14 | Soyuz TMA-19 ISS 23S | Soyuz FG | Baikonur Cosmodrome, Kazakhstan | manned transport vessel to the International Space Station |
| June 28 | Progress M-06M (ISS 38P) | Soyuz U | Baikonur Cosmodrome, Kazakhstan | unmanned cargo transport to the International Space Station |
| June | Metop 1 | Soyuz-2 | | |
| July 27 | Progress M-07-M (ISS 39P) | Soyuz U | Baikonur Cosmodrome, Kazakhstan | unmanned cargo transport to the International Space Station |
| July 29 | Space Shuttle Endeavour ISS-35-ULF5 | Shuttle Endeavour (STS-134) | the Kennedy Space Center, Florida, USA | shuttle visit to the International Space Station, delivery of Express Logistics Carrier 3 (ELC3) and Alpha Magnetic Spectrometer (AMS) to ISS |
| July 30 | AEHF 1 (Advanced Extremely High Frequency 1) | Atlas 5 | Cape Canaveral Air Force Station, Florida, USA | US military communications satellite |
| July | AMC 1R, Insat 4G | Ariane 5 | CSG Kourou, French Guiana | commercial communications satellite |
| July | Dragon C1 (COTS Demo 1) | Falcon 9 | Cape Canaveral Air Force Station, Florida, USA | first test flight of the Dragon spacecraft, duration four and a half hours |
| July | Sudansat 1 | Dnepr-1 | | |
| July | TacSat 1 | Falcon 1 | Reagan Test Site, Kwajalein Atoll, Marshall Islands | |
| July | Tugsat 1 | Dnepr 1 | | |
| August 31 | Progress M-08-M (ISS 40P) | Soyuz U | Baikonur Cosmodrome, Kazakhstan | unmanned cargo transport to the International Space Station |
| August | BSAT 3b, W3B | Ariane 5 | CSG Kourou, French Guiana | |
| August | Cassiope 1 | Falcon 1 | Reagan Test Site, Kwajalein Atoll, Marshall Islands | |
| August | Garpun N-1 | Proton M / Briz M | Baikonur Cosmodrome, Kazakhstan | military data relay satellite |
| August | TacSat 4 | Minotaur 4+ | Kodiak Launch Complex, Kodiak Island, Alaska, USA | first flight of the Minotaur 4+ |
| August | Uragan M / Glonass M27/M28/M29 | Proton M / Blok DM-2 | Baikonur Cosmodrome, Kazakhstan | three Russian navigation satellites |
| August | XM-5 | Proton | Baikonur Cosmodrome, Kazakhstan | radio broadcasting satellite |
| September 8 | Cosmo-SkyMed 4 | Delta 2 | Vandenberg Air Force Base, California, USA | Italian military synthetic aperture radar surveillance satellite |
| September 16 | Space Shuttle Discovery | Shuttle Discovery (STS-133) | the Kennedy Space Center, Florida, USA | shuttle visit to the International Space Station, delivery of Express Logistics Carrier 4 (ELC4) and Multi-Purpose Logistics Module (MLPM) to ISS |
| September 30 | Soyuz TMA-01M ISS 24S | Soyuz FG | Baikonur Cosmodrome, Kazakhstan | manned transport vessel to the International Space Station |
| September | Bissat | Kosmos-3M | Plesetsk Cosmodrome, Russia | |
| September | Eros C | Start-1 | Svobodny, Russia | Israeli Earth imaging satellite |
| September | GIOVE A2 | Soyuz-FG / Fregat | Baikonur Cosmodrome, Kazakhstan | demonstration satellite for Galileo navigation system |
| September | Globalstar 2 (1-6) | Soyuz 2.1b / Fregat | Baikonur Cosmodrome, Kazakhstan | six commercial communications satellites |
| September | HYDROS (Hydrosphere State, ESSP-07) | | | |
| September | Hylas | Soyuz 2-1a / Fregat | CSG Kourou, French Guiana | commercial communications satellite |
| September | Lapansat 2 | Dnepr-1 | Baikonur Cosmodrome, Kazakhstan | |
| September | Sich-2, RASAT, Edusat, NigeriaSat 2, NigeriaSat X, SpaceQuest (2 satellites) | Dnepr 1 | Dombarovskiy Launch Site, Yasny, Russia | Turkish remote sensing satellite (RASAT), Ukrainian remote sensing satellite (Sich 2M) |
| October 27 | Progress M-09M (ISS 41P) | Soyuz U | Baikonur Cosmodrome, Kazakhstan | unmanned cargo transport to the International Space Station |
| October | Bluesat | Dnepr-1 | Baikonur Cosmodrome, Kazakhstan | |
| October | Chang'e 2 | Long March 3A | Xichang Satellite Launch Center, Sichuan province, China | Chinese lunar orbiter |
| October | Dragon C2 (COTS Demo 2) | Falcon IX | Cape Canaveral Air Force Station, Florida, USA | |
| October | Elektro-L N1 | Zenit-3 / Fregat | Baikonur Cosmodrome, Kazakhstan | |
| October | Express AM-4 | Proton M / Briz M | Baikonur Cosmodrome, Kazakhstan | commercial communications satellites |
| October - December | Intelsat 17 | Zenit 3SL | | commercial communications satellite |
| October - December | Ka-Sat | Proton M / Briz M | Baikonur Cosmodrome, Kazakhstan | |
| October | Lunar Robotic 2 | Delta | | |
| October | NRO L-41 | Atlas V | | US spy satellite |
| October - December | NSS 14 | Proton | Baikonur Cosmodrome, Kazakhstan | commercial communications satellite |
| October | ORS 1 | Minotaur | | |
| October | Pleiades-HR 1, ELISA 1, ELISA 2, ELISA 3, ELISA 4, SSOT | Soyuz 2-1b / Fregat | CSG Kourou, French Guiana | earth observation satellite (Pleiades-HR 1), four electronic intelligence demonstrator satellites (ELISA) |
| October | SMEX-12 | Small | | |
| November 10 | ATV 2 (Johannes Kepler) | Ariane 5ES | CSG Kourou, French Guiana | unmanned supply ship to ISS |
| November 22 | Glory, E1P, HERMES, KySat 1 | Taurus XL | Vandenberg Air Force Base, California, USA | earth observation satellite (Glory) |
| November 30 | Soyuz TMA-21 ISS 25S | Soyuz FG | Baikonur Cosmodrome, Kazakhstan | manned transport vessel to the International Space Station |
| November | AFSPC 2 | Atlas V | Cape Canaveral Air Force Station, Florida | |
| November | AKS-1/2, AtmoCube, CAPE 1, CubeSat RAFT, Funsat, KatySat 1, KiwiSat, UCISat 1 | Dnepr-1 | Baikonur Cosmodrome, Kazakhstan | multiple small experimental and technology satellites |
| November | Galileo IOV1, IOV2 | Soyuz 2-1b / Fregat | CSG Kourou, French Guiana | 2 validation satellites for the Galileo navigation system |
| November | Hausat 2 | Dnepr-1 | Baikonur Cosmodrome, Kazakhstan | |
| November | Koreasat 6 | | CSG Kourou, French Guiana | commercial communications satellite |
| November | NRO L-27 | Delta-4M+ | Cape Canaveral Air Force Station, Florida | |
| November | Orbcomm 2-1, 2-2, 2-3 | Falcon Ie | Reagan Test Site, Kwajalein Atoll, Marshall Islands | commercial communications satellites |
| November | Spektr-R/RadioAstron | Zenit 3SLBF / Fregat SB | Baikonur Cosmodrome, Kazakhstan | radiotelescope |
| December 1 | NROL-49 | Delta 4 Heavy | Vandenberg Air Force Base, California, USA | US spy satellite |
| December 31 | LARES (Laser Relativity Satellite), AtmoCube, e-st@r, Goliat, OUFTI-1, PW-Sat 1, ROBUSTA, SwissCube 2, UNICubeSAT, XaTcobeo | Vega | CSG Kourou, French Guiana | first flight of the Vega |
| December | Cassiope 1 | Falcon I | | |
| December | Geizer N21 | Proton K | Baikonur Cosmodrome, Kazakhstan | |
| December | GPS 2F-2 | Delta 4 | Cape Canaveral Air Force Station, Florida, USA | navigation satellite |
| December | Kondor E 1 | Strela | Baikonur Cosmodrome, Kazakhstan | |
| December | Microscope | Ariane 5 | CSG Kourou, French Guiana | |
| December | Monitor IR1 | Rokot KM | | |
| December | Prognoz N11 | Proton K / Blok DM2 | Baikonur Cosmodrome, Kazakhstan | |
| December | Resurs-P 1 | Soyuz 2-1b | Baikonur Cosmodrome, Kazakhstan | Russian remote sensing satellite |
| December | Space-Based Surveillance System 1 (SBSS 1) | Minotaur IV | Vandenberg Air Force Base, California, USA | US military surveillance satellite to monitor orbiting satellites; first flight of the Minotaur IV |
| ??? | ADM-Aeolus | Vega | CSG Kourou, French Guiana | |
| ??? | AMC-5R | Zenit -3SLB / Blok DM-SLB | Baikonur Cosmodrome, Kazakhstan | commercial communications satellites |
| ??? | Argo (RapidEye 6) | Falcon 1 | Reagan Test Site, Kwajalein Atoll, Marshall Islands | commercial earth observation satellite |
| ??? | ATV 3 | Ariane 5 | CSG Kourou, French Guiana | |
| ??? | Cosmo Skymet F-1 | Vega | CSG Kourou, French Guiana | |
| ??? | Cygnus 1 | Taurus 2 | Wallops Flight Facility, Wallops Island, Virginia, USA | |
| ??? | Demo Launch | Falcon Ie | Reagan Test Site, Kwajalein Atoll, Marshall Islands | |
| ??? | Docking Cargo Module (DCM) | | | |
| ??? | Dragon C3 (COTS Demo 3) | Falcon IX | Cape Canaveral Air Force Station, Florida, USA | |
| ??? | DragonLab 1 | Falcon IX | Cape Canaveral Air Force Station, Florida, USA | |
| ??? | GCOM-B1 | | | |
| ??? | IXV (Intermediate Experimental Vehicle) | Vega | CSG Kourou, French Guiana | |
| ??? | Kanopus-V 2 | | | |
| ??? | KazSat-2 | | | commercial communications satellite |
| ??? | KEO | Ariane 5 | CSG Kourou, French Guiana | |
| ??? | Kompsat 5 | Dnepr 1 | Dombarovskiy Launch Site, Yasny, Russia | |
| ??? | Lebed | | | communications satellite |
| ??? | Mars Gravity Biosatellite | Falcon I | Reagan Test Site, Kwajalein Atoll, Marshall Islands | |
| ??? | MPE (Multiple Payload Ejector) | Falcon | | |
| ??? | MSG 3 | Ariane 5 | CSG Kourou, French Guiana | |
| ??? | MSG 4 | | CSG Kourou, French Guiana | |
| ??? | NRO L-P | Delta 4 Heavy | | |
| ??? | Parom | Soyuz-2-3 | | interorbital tug |
| ??? | Pleiades 2 | Soyuz 2 | CSG Kourou, French Guiana | earth observation satellite |
| ??? | Progress M-10-M (ISS 42P) | Soyuz U | Baikonur Cosmodrome, Kazakhstan | unmanned cargo transport to the International Space Station |
| ??? | S2M | Proton M / Briz M | Baikonur Cosmodrome, Kazakhstan | commercial mobile television broadcast satellite |
| ??? | SBIRS H-3 | Delta 4 Medium + | | |
| ??? | Seosat | | CSG Kourou, French Guiana | |
| ??? | Sicral 2 | Ariane 5 | CSG Kourou, French Guiana | |
| ??? | SkyTerra 1 (MSV 1) | Proton M / Briz M | Baikonur Cosmodrome, Kazakhstan | commercial communications satellite |
| ??? | SkyTerra 2 (MSV 2) | Proton M / Briz M | Baikonur Cosmodrome, Kazakhstan | commercial communications satellite |
| ??? | SmallSat-01 | | | |
| ??? | SPACETECH-09 | | | |
| ??? | Spektr-UF | Zenit -3M / Fregat-SB | Baikonur Cosmodrome, Kazakhstan | ultraviolet astronomical observatory |
| ??? | SSOT | Soyuz 2 | CSG Kourou, French Guiana | |
| ??? | Svea | Falcon Ie | Reagan Test Site, Kwajalein Atoll, Marshall Islands | |
| ??? | Swarm A, Swarm B, Swarm C | Vega | CSG Kourou, French Guiana | |
| ??? | Venus | | CSG Kourou, French Guiana | |
| ??? | ViaSat 1 | Proton | Baikonur Cosmodrome, Kazakhstan | commercial communications satellite |
| ??? | XSS-12 | Delta 2 | | |
| ??? | Yahsat 1A | Ariane 5 | CSG Kourou, French Guiana | commercial communications satellite |
| ??? | YahSat 1B | Proton M / Briz M | Baikonur Cosmodrome, Kazakhstan | commercial communications satellite |